When Cajun heat meets cheesy comfort, you get a pasta dish that’s downright irresistible. This Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce is a bold, flavor-packed spin on classic spaghetti, with a silky sauce that clings to every strand. The beef is seasoned with Cajun spices, creating a smoky, peppery kick that’s balanced by the luxurious creaminess of parmesan, mozzarella, and cheddar.

The best part? This dish feels like a restaurant indulgence, but it’s simple enough to make at home on a weeknight. Whether you’re feeding a hungry family or cooking to impress, it’s the kind of meal that invites second helpings and maybe even a little bread-dipping into that glorious sauce.

What Kind of Pasta Should I Use for Cajun Beef Spaghetti?

Classic spaghetti is the ideal choice—it holds the sauce beautifully while giving you that satisfying fork-twirl. But you can also try linguine, fettuccine, or bucatini for a twist. For a nuttier, heartier bite, whole wheat pasta is a great option.

Ingredients for Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce

Ground Beef – The hearty base that carries the Cajun flavors.
Cajun Seasoning – Smoky, peppery, and full of warmth.
Spaghetti – The classic pasta for maximum sauce coverage.
Heavy Cream – Creates a rich, velvety sauce.
Parmesan Cheese – Nutty and salty, it deepens the flavor.
Mozzarella Cheese – Melts for creamy, stretchy goodness.
Cheddar Cheese – Adds sharpness to balance the cream.
Garlic – Aromatic and savory.
Onion – Adds subtle sweetness.
Olive Oil – For sautéing and bringing everything together.
Fresh Parsley – A fresh, bright finish.

How to Make Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil and cook spaghetti until al dente. Reserve ½ cup of pasta water before draining.

Step 2: Brown the Beef

In a large skillet over medium-high heat, warm olive oil, add ground beef, and cook until browned. Drain excess fat if needed.

Step 3: Build the Flavor Base

Add onion and sauté until softened. Stir in garlic and most of the Cajun seasoning, cooking briefly until fragrant.

Step 4: Make the Sauce

Stir in heavy cream and bring to a gentle simmer. Add Parmesan, mozzarella, and cheddar, stirring until smooth.

Step 5: Combine and Serve

Toss the spaghetti into the sauce, adding pasta water as needed to loosen. Garnish with fresh parsley.

Serving and Storing Cajun Beef Spaghetti

Serve hot, ideally with crusty bread or a fresh green salad. Store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat gently over low heat with a splash of cream or milk to restore creaminess.

Frequently Asked Questions

Can I make this dish ahead of time?

Yes, cook the sauce and pasta separately, then combine when ready to serve.

Can I use chicken instead of beef?

Absolutely, chicken or even shrimp works well with the Cajun flavors.

Is it very spicy?

It has a mild heat; adjust Cajun seasoning to taste.

Can I freeze it?

It’s best enjoyed fresh, but you can freeze the sauce separately for up to 2 months.

Want More Pasta Ideas with a Twist?

If you love this Cajun Beef Spaghetti, you might also enjoy:

Creamy Garlic Parmesan Chicken Pasta
Cajun Shrimp Alfredo Linguine
Spicy Sausage and Pepper Penne
Baked Ziti with Ricotta and Spinach
Chicken Pesto Tortellini

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Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce

Author: Jam Scott
Total Time: 40 minutes
Yield: 6 servings

Print Recipe

Description

Bold, creamy, and weeknight-friendly—this Cajun Beef Spaghetti swirls al dente noodles with a velvety three-cheese parmesan sauce and savory Cajun-spiced beef. It’s the perfect mash-up of cozy comfort and zesty Southern heat.

Instructions

1. Bring a large pot of salted water to a boil; cook spaghetti to al dente. Reserve 1/2 cup pasta water; drain.

2. Heat olive oil in a large skillet over medium-high. Add ground beef, break it up, and cook until no longer pink; drain excess fat if needed.

3. Add onion; saute 3 to 4 minutes until translucent. Stir in garlic and 1 tablespoon Cajun seasoning; cook 30 seconds until fragrant.

4. Stir in tomato paste; cook 1 minute to caramelize.

5. Pour in beef broth, scraping up browned bits; simmer 2 minutes to reduce slightly.

6. Lower heat to medium-low; stir in heavy cream and butter. Simmer gently 2 to 3 minutes until slightly thickened.

7. Off heat, stir in Parmesan, mozzarella, and cheddar until melted and smooth. Loosen with reserved pasta water if needed.

8. Add Worcestershire, remaining 1/2 tablespoon Cajun seasoning, salt, pepper, and sugar (if using). Taste and adjust.

9. Toss spaghetti into the sauce until coated. Fold in parsley.

10. Garnish with parsley and optional red pepper flakes. Serve hot.

Notes

Cheese matters: freshly grated Parmesan melts smoother than pre-shredded.

Sauce control: keep heat moderate after adding cream/cheese; thin with pasta water if needed.

Heat level: Cajun blends vary—start with 1 tablespoon, add more to taste.

Prep Time: 15 minutes
Cook Time: 25 minutes
Category: Pasta, Dinner
Method: Stovetop
Cuisine: Cajun-Italian

Nutrition

Serving Size: 1.5 cups
Calories: 620
Sugar: 6
Sodium: 920
Fat: 32
Saturated Fat: 17
Unsaturated Fat: 13
Trans Fat: 0.5
Carbohydrates: 48
Fiber: 3
Protein: 33
Cholesterol: 115

Keywords: cajun beef spaghetti, creamy parmesan sauce, three cheese spaghetti, ground beef pasta