Chicken Rotini in Mozzarella Velveeta Sauce

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Golden, juicy Cajun-seasoned chicken paired with tender rotini pasta and drenched in a rich, velvety mozzarella Velveeta sauce? Yes, please! This dish is a full-on flavor bomb, combining spice, creaminess, and cheesy comfort in every bite. Perfect for weeknights when you need something filling and fast, but also impressive enough for a cozy dinner with friends or family.

The rotini noodles catch every swirl of sauce, while the chicken brings just the right kick to keep things interesting. This meal is deeply satisfying, especially when topped with a sprinkle of herbs and maybe a little extra cheese if you’re feeling bold. And the best part? It all comes together in under 30 minutes.

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What Kind of Chicken Works Best?

For the most flavorful and juicy results, boneless, skinless chicken thighs are a fantastic choice. They cook quickly and stay moist, even with high-heat searing. But if you’re leaning toward leaner cuts, boneless chicken breasts also work well—just be mindful not to overcook them. The real magic lies in the Cajun seasoning, which adds that deep Southern flavor we crave.

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Ingredients for the Cajun Chicken Rotini in Creamy Mozzarella Velveeta Sauce

Chicken: This is the protein backbone of the dish. Well-seasoned and pan-seared chicken adds both texture and flavor.

Rotini Pasta: Its spiral shape is perfect for soaking up all that creamy cheese sauce. You can substitute with penne or fusilli if needed.

Velveeta Cheese: Melts effortlessly into a smooth, creamy sauce. It creates the perfect cheesy base with zero clumping.

Mozzarella Cheese: Adds that gooey, stretchy cheesiness and balances out the processed Velveeta with some real-deal dairy richness.

Cajun Seasoning: Brings bold flavor, mild heat, and a Southern-style kick that ties the chicken and sauce together beautifully.

Heavy Cream: Helps smooth out the sauce while enhancing its richness.

Butter: Used to sauté the chicken and add that luscious, buttery undertone.

Garlic Powder & Onion Powder: Layer in additional flavor without extra prep work.

Parsley (optional): A finishing herb for color and fresh, slightly peppery notes.

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How To Make the Cajun Chicken Rotini in Creamy Mozzarella Velveeta Sauce

Step 1: Season and Sear the Chicken

Cut the chicken into bite-sized cubes. Generously coat with Cajun seasoning, garlic powder, and onion powder. Heat butter in a large skillet over medium-high heat. Sear the chicken pieces until golden brown on all sides and cooked through. Remove and set aside.

Step 2: Cook the Rotini

In a large pot of salted boiling water, cook the rotini according to package directions until al dente. Drain and set aside.

Step 3: Make the Creamy Cheese Sauce

In the same skillet used for the chicken, lower the heat to medium. Add a bit more butter if needed, then pour in the heavy cream. Stir until warm and just starting to bubble. Add Velveeta cubes and stir continuously until melted and smooth. Stir in shredded mozzarella until fully combined.

Step 4: Combine Everything

Return the cooked chicken to the skillet. Add in the drained rotini and gently fold everything together until the pasta is well coated and the chicken is evenly distributed.

Step 5: Garnish and Serve

Sprinkle with chopped parsley or a little extra mozzarella if desired. Serve hot and enjoy the melty, spicy goodness!

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How to Serve and Store Cajun Chicken Rotini

Serving: This dish is best enjoyed immediately while the sauce is hot and gooey. Serve it in shallow pasta bowls for maximum sauce coverage and top with a bit of fresh parsley or a drizzle of extra cream if you’re feeling fancy. A side salad or garlic bread rounds out the meal beautifully.

Storing: Let the pasta cool completely before storing. Transfer to an airtight container and refrigerate for up to 3 days. To reheat, warm gently on the stovetop with a splash of cream or milk to revive the sauce.

Freezing: While technically possible, freezing creamy pasta can cause texture changes. If you do freeze, let it thaw in the fridge overnight and reheat slowly with added cream to help emulsify the sauce again.

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Frequently Asked Questions

Can I make this recipe ahead of time?

Yes! You can prep the chicken and even the cheese sauce a day in advance. Store them separately in the fridge, then combine and reheat when ready to serve.

What if I don’t have Velveeta?

You can use cream cheese or a blend of cheddar and mozzarella. Velveeta gives that ultra-smooth texture, but it’s not a dealbreaker.

Is this dish very spicy?

The spice level is moderate with classic Cajun seasoning. You can reduce the amount or use a milder blend if cooking for kids or spice-sensitive guests.

Can I substitute the pasta?

Absolutely. Penne, fusilli, or even elbow macaroni will work well. Just pick a shape that holds sauce nicely.

How do I make it healthier?

Swap out the heavy cream for half-and-half and use a lighter cheese blend. Grilled chicken breast instead of pan-fried thighs can also cut fat.

Can I make this vegetarian?

Sure! Skip the chicken and use sautéed mushrooms, roasted cauliflower, or a plant-based protein.

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Want More Pasta Ideas with a Kick?

If this Cajun Chicken Rotini has you craving even more comfort with bold flavor, try these next:

• Creamy Garlic Parmesan Tortellini with Sausage and Broccoli for a veggie-packed twist.
• Cheesesteak Tortellini in Rich Provolone Sauce if you love cheesy sauces with a meaty bite.
• Creamy Cheesy Garlic Butter Rigatoni with Savory Beef for a satisfying weeknight wonder.
• Rattlesnake Pasta if you’re into extra heat and Tex-Mex flavor fusion.
• Creamy Cajun Steak Alfredo for another bold creamy-meets-spicy combination.

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Save This Pin + Share Your Results

📌 Save this recipe to your Pinterest dinner or comfort food board so you can come back to it anytime.

And let me know in the comments how yours turned out. Did you use thighs or go with chicken breast? Add any heat boosters like cayenne or jalapeños?

I love seeing how everyone makes these recipes their own. Questions and tips are always welcome—let’s cook and connect!

👉 Follow me on Pinterest @Hallarecipes for more comforting, creamy, bold recipes like this one.

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