A bold, comforting dish that blends the smoky heat of Cajun seasoning with the velvety richness of a creamy garlic mozzarella sauce, this Cajun Chicken Spaghetti is perfect for weeknights yet impressive enough for guests. Each forkful gives you tender, juicy chicken with a crispy seared crust, twirled into perfectly coated strands of pasta that are impossible to resist.

The secret lies in balancing spice and cream. The Cajun rub infuses the chicken with a warm, peppery bite, while the garlic and mozzarella sauce mellows it out, creating a silky, luscious coating for every bite of spaghetti. It’s the kind of meal that earns a permanent place in your dinner rotation.

What Kind of Spaghetti Should I Use?

For this recipe, traditional durum wheat spaghetti works beautifully, holding up to the thick, creamy sauce without becoming mushy. If you prefer a lighter touch, you can opt for whole wheat or gluten-free pasta, but be sure to slightly undercook it before tossing it in the sauce so it finishes to perfection in the pan.

Ingredients for the Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce

Chicken breast – Lean, protein-packed, and perfect for holding onto that flavorful Cajun rub.
Cajun seasoning – Brings smoky heat, paprika warmth, and a subtle kick that defines this dish.
Spaghetti – A classic pasta shape that twirls beautifully with creamy sauce.
Butter & olive oil – The dynamic duo for searing the chicken to a golden crust.
Garlic – Freshly minced for maximum aroma and depth.
Heavy cream – The base of the rich, velvety sauce.
Mozzarella cheese – Melts into the cream for an indulgent, stretchy texture.
Chicken broth – Adds savory depth and keeps the sauce from being too heavy.
Parsley – A fresh finish that brightens every bite.

How To Make the Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce

Step 1: Prepare and Season the Chicken

Pat the chicken breasts dry with paper towels. Rub both sides generously with Cajun seasoning, pressing it in so it adheres well. This step ensures the flavor penetrates the meat.

Step 2: Sear to Perfection

In a large skillet over medium-high heat, melt butter with olive oil. Add the chicken and sear for about 4-5 minutes on each side, until golden brown and cooked through. Remove from the skillet and set aside to rest.

Step 3: Start the Sauce Base

Lower the heat to medium. In the same skillet, add a bit more butter if needed, then sauté the minced garlic until fragrant, about 30 seconds.

Step 4: Create the Creamy Goodness

Pour in heavy cream and chicken broth, stirring to combine. Let it simmer gently for 3-4 minutes, allowing the flavors to meld.

Step 5: Add the Cheese

Reduce heat to low and stir in the shredded mozzarella. Whisk until fully melted and the sauce becomes silky smooth.

Step 6: Cook the Pasta

Meanwhile, cook the spaghetti according to package directions, but stop 1 minute short of al dente. Reserve a cup of pasta water before draining.

Step 7: Combine and Serve

Add the spaghetti to the skillet with the sauce, tossing to coat. If the sauce is too thick, add a splash of pasta water until it reaches your desired consistency. Slice the rested chicken and place it on top of the pasta. Garnish with chopped parsley and serve immediately.

Serving and Storing Cajun Chicken Spaghetti

This dish is best served fresh while the sauce is hot and the cheese is stretchy. Pair it with a crisp side salad or buttery garlic bread for a complete meal. If you have leftovers, store them in an airtight container in the refrigerator for up to 3 days. Reheat gently on the stovetop with a splash of cream or broth to revive the sauce.

Frequently Asked Questions

Can I use chicken thighs instead of breasts?

Absolutely. Chicken thighs will be juicier and add a richer flavor to the dish.

How spicy is this recipe?

It has a medium heat level. You can tone it down by using less Cajun seasoning or choose a mild blend.

Can I make it ahead?

You can prepare the sauce and cook the pasta ahead of time, but for best results, sear the chicken fresh and toss everything together before serving.

What can I substitute for heavy cream?

Half-and-half works, though the sauce will be slightly less rich. For a dairy-free option, try unsweetened coconut cream.

Will Parmesan work instead of mozzarella?

Yes, but it will give the sauce a saltier, nuttier taste and less stretch.

Want More Pasta Dinner Ideas?

If you love this Cajun Chicken Spaghetti, you’ll probably enjoy these other favorites:

Rattlesnake Pasta for a creamy, spicy twist with peppers and chicken.
One Pot Creamy Beef and Garlic Butter Pasta when you crave hearty comfort food.
Creamy Garlic Parmesan Tortellini with Sausage and Broccoli for a cheesy, veggie-packed option.
Red Pepper Rigatoni – A Creamy Bold Pasta Delight for something smoky and colorful.
Cheesesteak Tortellini in Rich Provolone Sauce for indulgent cheesesteak-inspired flavors.

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you go heavy on the Cajun spice or keep it mild? Did you swap in Parmesan for mozzarella?

I love hearing how others make these recipes their own. Questions are welcome too—let’s help each other cook smarter.

Find more recipes on my Pinterest – Life with Jam.

Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce

Author: Jam Scott
Total Time: 40 minutes
Yield: 4 servings

Print Recipe

Description

Spicy, smoky Cajun-rubbed chicken meets a rich, velvety garlic-mozzarella cream sauce, all tossed with twirl-worthy spaghetti. It’s a weeknight-easy pasta that tastes like your favorite bistro—bold, creamy, and comforting.