Rich, spicy, creamy—this Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream is the kind of weeknight comfort food that hits every craving. Picture golden-seared Cajun chicken nestled against penne pasta drenched in a velvety garlic parmesan sauce, finished with a generous shower of fresh parsley. Whether you’re serving this to guests or just treating yourself, it’s the perfect marriage of heat, cheese, and creamy indulgence.

The Cajun spices bring a smoky, bold kick to the chicken, balancing beautifully with the mellow, cheesy sauce. Meanwhile, the penne holds onto every bit of that luscious creaminess, making each bite a little pocket of joy. It’s fast enough for a weeknight, impressive enough for a dinner party.

What Kind of Cajun Seasoning Should I Use?

Go for a high-quality Cajun blend—store-bought or homemade. Look for a mix that balances paprika, garlic, onion, thyme, and a touch of cayenne. If you’re sensitive to spice, opt for a mild blend and add heat later with chili flakes. For maximum flavor, rub it generously into the chicken before searing.

Ingredients for the Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

Chicken Thighs or Breasts: Boneless, skinless chicken seared to golden perfection and infused with Cajun spices.

Penne Pasta: Its tubular shape holds the creamy sauce beautifully. Feel free to sub with rigatoni or ziti if you prefer.

Cajun Seasoning: Adds that smoky heat and deep flavor to the chicken.

Garlic: Essential for that rich, aromatic base of the sauce.

Heavy Cream: The key to achieving a silky, decadent sauce.

Parmesan Cheese: Freshly grated works best—it melts into the sauce, giving it body and that nutty-salty punch.

Butter and Olive Oil: Used to sear the chicken and start the sauce base.

Parsley: Brightens up the richness and adds a fresh finish.

Salt & Pepper: For seasoning throughout the cooking process.

How To Make the Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

Step 1: Season and Sear the Chicken

Pat the chicken dry and rub generously with Cajun seasoning on both sides. In a large skillet, heat olive oil and butter over medium-high heat. Sear the chicken for about 4–5 minutes per side until deeply golden and cooked through. Transfer to a plate and cover.

Step 2: Cook the Penne

Bring a large pot of salted water to a boil. Cook penne according to package directions until al dente. Reserve 1/2 cup of pasta water, then drain and set aside.

Step 3: Make the Garlic Parmesan Cream Sauce

In the same skillet used for the chicken, reduce heat to medium. Add a bit more butter if needed and sauté minced garlic for about 30 seconds until fragrant. Pour in the heavy cream and stir, scraping up the browned bits. Let it simmer for 2–3 minutes.

Step 4: Add Cheese and Pasta

Whisk in grated Parmesan cheese until smooth and thickened. Season with salt and black pepper to taste. Add the cooked penne and a splash of reserved pasta water to loosen the sauce as needed.

Step 5: Slice and Serve the Chicken

Slice the seared chicken and serve it on top of the creamy penne. Garnish with fresh parsley and more grated Parmesan if desired.

How to Serve and Store This Cheesy Penne and Cajun Chicken

Serving Tips: Serve it hot from the skillet, garnished with extra parsley and a bit more grated Parmesan. A side of garlic bread or roasted broccoli makes a complete and hearty meal. If you’re entertaining, this dish pairs wonderfully with a crisp white wine or sparkling lemonade.

Storing Tips: Allow any leftovers to cool completely before transferring to an airtight container. It keeps well in the fridge for up to 4 days. Reheat in a skillet with a splash of milk or cream to restore the sauce’s texture. Avoid microwaving the chicken too long to prevent it from drying out.

Frequently Asked Questions

Can I use chicken breasts instead of thighs?

Absolutely. Chicken breasts work just as well; just be careful not to overcook them. You might want to pound them to even thickness for quicker, more even cooking.

Can I make this dish ahead of time?

Yes! Cook everything and keep the sauce and pasta separate until ready to serve. Warm both up and combine before serving to keep the sauce creamy.

What can I substitute for heavy cream?

You can use half-and-half or whole milk with a bit of cream cheese or flour slurry to help thicken the sauce. It won’t be as rich, but still delicious.

Is this dish freezer-friendly?

The chicken freezes well, but the cream-based sauce may separate. For best results, freeze just the chicken and make the sauce fresh when reheating.

Can I make this vegetarian?

Sure! Swap the chicken with sautéed mushrooms, roasted cauliflower, or even crispy tofu. Just be sure to season them well with Cajun spices.

How spicy is the Cajun seasoning?

That depends on the brand or recipe. Start light and build up if you’re unsure. You can always add chili flakes at the end for more kick.

Want More Chicken Pasta Ideas?

If you love this cheesy Cajun creation, you’ll definitely want to check out these other mouthwatering pasta dishes:

Creamy Garlic Parmesan Tortellini with Sausage and Broccoli – the ultimate cozy bowl of creamy comfort.
Creamy Cajun Steak Alfredo – bold Cajun flavors meet silky Alfredo.
Cheesesteak Tortellini in Rich Provolone Sauce – hearty, cheesy, and crave-worthy.
Skillet Ricotta Pasta with Roasted Broccoli – a weeknight winner with creamy ricotta.
One Pot Creamy Beef and Garlic Butter Pasta – no-fuss, all-flavor in one pot.

And for more daily inspiration, don’t forget to follow along on my Pinterest board — Life with Jam is always serving something delicious.

Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

Author: Jam Scott
Total Time: 35 minutes
Yield: 4 servings

Print Recipe

Description

Golden-seared Cajun chicken served with cheesy, garlic-rich penne pasta—this dish is bold, creamy, and perfect for both busy weeknights and casual entertaining. The garlic parmesan sauce ties it all together with buttery richness.