Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce is the kind of skillet dinner that gets cheers at the table. It takes the soul-warming comfort of spaghetti and dials it up with spicy Cajun flavors, melty cheese, and rich, savory beef. And when all that deliciousness is baked together in a bubbling skillet? Let’s just say don’t expect leftovers.

The sauce is ultra-creamy thanks to a trio of cheeses—sharp Parmesan, gooey mozzarella, and mild cheddar—swirled into a velvety Cajun-seasoned base. Topped with deeply seasoned ground beef and a sprinkle of fresh parsley, this dish is both indulgent and packed with flavor. Whether you’re feeding a hungry family or just craving some serious comfort, this recipe delivers bold flavor in every forkful.

What Kind of Spaghetti Should I Use?

Regular spaghetti noodles work perfectly for this dish, but if you want a slightly heartier texture, try bucatini or even linguine. Just avoid angel hair as it cooks too quickly and can get mushy under all that cheesy sauce. Make sure to cook your pasta al dente so it can hold up to the creamy sauce and beefy topping without going limp.

Ingredients for the Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce

Ground beef: Provides savory richness and meaty texture that pairs beautifully with the cheese sauce.
Spaghetti: The base of the dish, best cooked to al dente so it soaks up the sauce without breaking down.
Cajun seasoning: Adds that signature smoky heat and Southern depth. You can adjust it for more or less spice.
Garlic: Essential for a warm, aromatic backbone to the sauce.
Heavy cream: Creates the luscious base for our cheese blend to melt into.
Parmesan cheese: Sharp and salty, it brings depth and balances the creamy sauce.
Cheddar cheese: Adds mild creaminess and that familiar comfort flavor.
Mozzarella cheese: For stretch and melt factor—an ooey-gooey essential.
Butter: Helps sauté the garlic and deepen the flavor of the sauce.
Fresh parsley: Brightens the final dish and adds a touch of freshness.
Salt & pepper: Simple seasonings to bring balance and enhance all the flavors.

How To Make the Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce

Step 1: Cook the Spaghetti

Bring a large pot of salted water to a boil and cook the spaghetti according to the package instructions until al dente. Drain and set aside.

Step 2: Brown the Beef

In a large oven-safe skillet, cook the ground beef over medium-high heat until browned and cooked through. Drain any excess grease and season with half of the Cajun seasoning. Transfer to a bowl and set aside.

Step 3: Build the Sauce Base

In the same skillet, melt the butter over medium heat. Add the minced garlic and cook for 30 seconds until fragrant. Pour in the heavy cream and stir in the remaining Cajun seasoning. Bring to a gentle simmer.

Step 4: Add the Cheese

Reduce heat to low. Stir in the Parmesan, cheddar, and mozzarella cheeses until melted and smooth. Season with salt and pepper to taste.

Step 5: Combine with Pasta

Toss the cooked spaghetti into the cheese sauce, coating it well. Flatten the pasta into an even layer in the skillet.

Step 6: Top with Beef and Bake

Spoon the seasoned beef over the top of the cheesy spaghetti. Sprinkle with extra cheese if desired. Transfer the skillet to a preheated oven (375°F) and bake for 10-12 minutes, or until bubbly and golden on top.

Step 7: Garnish and Serve

Remove from the oven, sprinkle with chopped parsley, and serve immediately.

How to Serve and Store Creamy Cajun Beef Spaghetti

This dish is best served straight out of the skillet while the cheese is still gooey and the edges are crisped to perfection. A simple side salad or some garlic bread rounds out the meal beautifully. If you’re serving a crowd, place the hot skillet right at the center of the table and let everyone help themselves.

To store leftovers, let the spaghetti cool completely, then transfer to an airtight container. It will keep well in the fridge for up to 4 days. Reheat in the microwave or oven with a splash of cream or milk to bring the sauce back to life.

Frequently Asked Questions

How spicy is this dish?

The heat level depends on your Cajun seasoning. Most blends have a mild-to-medium spice, but feel free to add cayenne pepper if you want to turn up the heat.

Can I use ground turkey or chicken instead of beef?

Absolutely! Ground turkey or chicken will still taste fantastic with the Cajun spices and cheese sauce.

What if I don’t have an oven-safe skillet?

You can prepare the pasta and beef mixture in a regular pan, then transfer everything to a baking dish for the final step in the oven.

Can I make this ahead of time?

Yes! Assemble the dish completely, cover, and refrigerate it. When ready to serve, bake it covered at 375°F for about 20 minutes, then uncover and bake until bubbly.

Is this freezer-friendly?

It freezes well, though the texture may be slightly creamier when fresh. Store in a freezer-safe container for up to 2 months.

What cheeses can I substitute?

You can use Colby Jack or Monterey Jack in place of cheddar, or Gruyère for an extra punch of flavor.

Want More Pasta Dinner Ideas?

If you love this creamy Cajun beef spaghetti, you’ll probably enjoy these other satisfying meals:

Creamy Garlic Parmesan Tortellini with Sausage and Broccoli for a weeknight-friendly twist on Alfredo.
One Pot Creamy Beef and Garlic Butter Pasta when you want maximum flavor with minimal cleanup.
Skillet Ricotta Pasta with Roasted Broccoli for a veggie-packed creamy option.
Cheesy Baked Tortellini with Meat Sauce if you’re craving a baked pasta night.
Creamy Cheesy Garlic Butter Rigatoni with Savory Beef for another bold, meaty classic.

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time: Life with Jam on Pinterest.

And let me know in the comments how yours turned out! Did you make it extra spicy? Add a sprinkle of red pepper flakes or swap in a different cheese? I’d love to hear your twist.

Questions are welcome too—let’s help each other create weeknight wins with serious flavor.

Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce

Author: Jam Scott
Total Time: 40 minutes
Yield: 4 servings

Print Recipe

Description

This Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce is the ultimate comfort skillet dinner. A luscious cheese blend melts into a Cajun-spiced cream sauce, tossed with spaghetti and topped with savory seasoned beef. Finished in the oven until bubbly and golden, it’s a bold, satisfying dish that brings the flavor—and leftovers are rare!

Instructions

1. Bring a large pot of salted water to a boil. Cook spaghetti according to package directions until al dente. Drain and set aside.

2. In a large oven-safe skillet, cook ground beef over medium-high heat until browned. Drain excess grease. Season with 1 teaspoon of Cajun seasoning. Transfer beef to a bowl.

3. In the same skillet, melt butter over medium heat. Add garlic and sauté for 30 seconds until fragrant.

4. Pour in heavy cream. Stir in remaining 1 teaspoon Cajun seasoning and bring to a gentle simmer.

5. Reduce heat to low. Add Parmesan, cheddar, and mozzarella cheese. Stir until melted and smooth. Season with salt and pepper.

6. Add the cooked spaghetti to the cheese sauce and toss to coat evenly. Flatten the pasta in the skillet.

7. Spoon the cooked beef over the top. Sprinkle with extra cheese if desired.

8. Transfer skillet to preheated oven at 375°F. Bake for 10–12 minutes until bubbly and golden on top.

9. Remove from oven. Garnish with chopped parsley and serve hot.