Cajun Chicken Bowtie Pasta with Garlic Cheese Sauce

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Creamy Cajun Chicken Bowtie Pasta with Garlic Cheese Sauce is the definition of comfort food with a spicy twist. The smoky sear of Cajun-seasoned chicken, tender bowtie pasta, and silky cheese sauce loaded with garlic come together in a rich, flavor-packed bowl that feels like a Southern hug. It’s hearty enough for a cozy family dinner but delicious enough to impress guests on a weeknight.

Each bite is a balance of spice, creaminess, and savory cheese that clings to the pasta and juicy grilled chicken slices. This is one of those one-pan meals that hits every note — comforting, quick, and a little bold. Whether you’re looking for a new weeknight favorite or something to serve with garlic bread and a glass of white wine, this dish belongs on repeat.

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What Kind of Bowtie Pasta Should I Use?

Farfalle, also known as bowtie pasta, is ideal for this creamy Cajun recipe because its shape holds sauce in every fold and ridge. You can use regular or whole wheat, but al dente is key for the best texture. If you want a gluten-free version, swap in chickpea or lentil bowties and adjust the cooking time slightly.

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Ingredients for the Creamy Cajun Chicken Bowtie Pasta

Chicken Breast – Boneless and skinless, this is the protein that soaks up the Cajun spice and chars beautifully.

Cajun Seasoning – The smoky, spicy rub that defines the dish. Use store-bought or make your own blend.

Bowtie Pasta (Farfalle) – This pasta captures the garlic cheese sauce in its ridges and holds up well to the hearty chicken.

Heavy Cream – Provides the rich, silky base for the cheese sauce.

Garlic – Fresh minced garlic adds sharpness and warmth that pairs perfectly with the cheese and spice.

Cheddar Cheese – A sharp, melty cheese that thickens the sauce and brings rich flavor.

Parmesan Cheese – For that salty umami edge and a more complex cheesy depth.

Butter – Used for searing and adding flavor to the base of the sauce.

Olive Oil – Helps to sear the chicken evenly and brings richness.

Salt & Pepper – Essential for balancing flavors.

Parsley (optional) – A fresh finish that cuts through the creaminess.

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How To Make the Creamy Cajun Chicken Bowtie Pasta

Step 1: Season and Sear the Chicken

Start by patting your chicken breasts dry, then rub both sides generously with Cajun seasoning, salt, and pepper. Heat a combination of butter and olive oil in a large skillet over medium-high heat. Sear the chicken for 5–6 minutes on each side until golden brown and cooked through. Remove and let it rest before slicing.

Step 2: Cook the Bowtie Pasta

While the chicken cooks, bring a pot of salted water to a boil and cook the bowtie pasta until al dente. Drain and set aside, reserving about 1/2 cup of pasta water.

Step 3: Build the Garlic Cheese Sauce

In the same skillet used for the chicken (don’t clean it—those brown bits mean flavor!), reduce heat to medium and add more butter. Stir in minced garlic and cook until fragrant, about 30 seconds. Pour in heavy cream and simmer gently, stirring often.

Step 4: Melt the Cheese

Add the shredded cheddar and grated parmesan slowly, stirring until fully melted and smooth. If the sauce feels too thick, stir in some of the reserved pasta water for desired consistency.

Step 5: Combine Pasta and Sauce

Toss the cooked bowtie pasta into the garlic cheese sauce, folding gently to coat every piece. Let it warm together for 2–3 minutes so the pasta fully absorbs the flavors.

Step 6: Add the Chicken

Slice the rested Cajun chicken and lay it generously over the creamy pasta. Sprinkle with chopped parsley for a touch of color and freshness.

Step 7: Serve and Enjoy

Serve hot with garlic bread or a crisp green salad. This dish is rich, bold, and best enjoyed fresh out of the pan.

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Serving and Storing Creamy Cajun Chicken Bowtie Pasta

This dish is best served hot, right after the sauce and chicken are combined with the pasta. The cheesy garlic sauce thickens slightly as it sits, which makes the flavors even more comforting. Pair with garlic bread or roasted veggies for a full meal.

If you’re meal prepping or have leftovers, store the pasta in an airtight container in the fridge for up to 4 days. To reheat, add a splash of cream or milk in a skillet over low heat to revive the sauce without drying out the chicken. Avoid microwaving for too long, as it can overcook the chicken and break the sauce.

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Frequently Asked Questions

How spicy is this dish?

The heat level depends on your Cajun seasoning. Some blends are mild, while others bring serious heat. Start with a moderate amount and add more if you love spice.

Can I use a different type of pasta?

Absolutely. Penne, rigatoni, or even fettuccine work well. Just make sure to cook until al dente so the pasta doesn’t turn mushy in the sauce.

What can I substitute for heavy cream?

You can use half-and-half or whole milk with a touch of cream cheese. The sauce won’t be quite as rich, but still delicious.

Is this recipe gluten-free?

Not by default, but you can make it gluten-free by using gluten-free bowtie pasta and double-checking your Cajun seasoning.

Can I make this vegetarian?

Yes! Omit the chicken and use roasted vegetables like mushrooms, bell peppers, or zucchini for a hearty twist.

Can I freeze it?

It’s not recommended. Cream-based sauces tend to separate when frozen and reheated, affecting the texture.

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Want More Pasta Ideas with a Kick?

If this Creamy Cajun Chicken Bowtie Pasta hit the spot, you’ll love these other bold and comforting pasta favorites from Life with Jam:

• Creamy Tortellini Recipe for a cheesy, crowd-pleasing dinner.
• Creamy Garlic Parmesan Tortellini with Sausage and Broccoli if you’re craving a garlic-forward twist.
• Cheesesteak Tortellini in Rich Provolone Sauce brings cheesy Philly vibes into pasta night.
• Red Pepper Rigatoni for a spicy, smoky vegetarian alternative.
• Rattlesnake Pasta with creamy heat and a sassy name to match.

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Tried this pasta? Let me know how it turned out! Did you crank up the spice or go light on the heat? Add mushrooms? I’d love to hear your spin in the comments below. And if you have any questions, drop them too—let’s make dinner better together!

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