Creamy Cajun Chicken Penne Pasta with Garlic Mozzarella Sauce

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Bold, spicy, creamy, and comforting—this Creamy Cajun Chicken Penne Pasta with Garlic Mozzarella Sauce is the kind of dish that makes weeknights feel like a restaurant indulgence. Perfectly seared Cajun-spiced chicken rests on a bed of penne pasta smothered in a garlicky mozzarella cream sauce, finished with a sprinkle of fresh herbs. It’s a beautiful blend of heat and richness, with a silky sauce that clings to every bite of pasta.

Whether you’re craving a flavorful date night dinner or need something quick yet satisfying for the family, this dish is a guaranteed hit. It’s comfort food with a kick—easy to prepare, wildly delicious, and sure to impress anyone who gets a plateful.

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What Makes Cajun Chicken Pasta So Irresistible?

It’s all about the flavor layers. Cajun seasoning brings bold smokiness, a touch of heat, and savory depth to the chicken. The mozzarella cream sauce softens that heat and adds luscious body to the dish. Pasta acts as the perfect carrier, soaking up every flavorful element, while the seared chicken offers texture and spice. It’s a crave-worthy balance of creamy, spicy, and satisfying.

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Ingredients for the Creamy Cajun Chicken Penne Pasta

Chicken Breasts – Lean, juicy, and perfect for searing. Slice into strips after cooking for a hearty, protein-packed topping.

Cajun Seasoning – This spice mix is essential for giving the chicken its signature smoky, spicy kick. Homemade or store-bought both work beautifully.

Olive Oil – Used to sear the chicken and infuse it with flavor. Also helps achieve that crispy golden crust.

Penne Pasta – Penne is ideal because its ridges and hollow center grab onto the creamy sauce for a perfect bite every time.

Butter – Adds richness to the sauce and helps bloom the garlic.

Garlic – Fresh minced garlic gives the sauce its bold, aromatic base.

Heavy Cream – The heart of the sauce. It delivers velvety texture and balances out the spices.

Mozzarella Cheese – Adds stretch and creamy flavor to the sauce. Melts down to a smooth, silky consistency.

Parmesan Cheese – Offers salty depth and a little nutty edge to balance the mozzarella.

Salt & Pepper – Season to taste. Start light and adjust once everything comes together.

Parsley (optional) – A fresh finish that brightens the dish and adds a pop of color.

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How To Make the Creamy Cajun Chicken Penne Pasta

Step 1: Prep and Cook the Chicken

Pat chicken breasts dry and rub both sides with Cajun seasoning. Heat olive oil in a skillet over medium-high heat. Sear the chicken for 5–6 minutes per side, or until golden brown and cooked through. Transfer to a cutting board and let rest.

Step 2: Boil the Penne

While the chicken cooks, bring a large pot of salted water to a boil. Cook the penne according to package instructions until al dente. Drain and set aside.

Step 3: Make the Garlic Mozzarella Sauce

In the same skillet, reduce heat to medium. Add butter and minced garlic. Sauté for 1 minute until fragrant. Pour in heavy cream and bring to a gentle simmer. Stir in mozzarella and parmesan, mixing until melted and smooth.

Step 4: Combine Pasta and Sauce

Toss the cooked penne into the skillet with the sauce. Stir to coat the pasta thoroughly in the creamy, cheesy goodness. Add salt and pepper to taste.

Step 5: Slice and Add the Chicken

Slice the rested Cajun chicken into strips. Plate the pasta and top generously with chicken slices. Sprinkle with chopped parsley if desired.

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Serving and Storing This Creamy Cajun Pasta

Serve this pasta hot and fresh from the skillet, when the sauce is at its creamiest. It pairs well with a crisp side salad, crusty garlic bread, or steamed veggies. Garnish with extra parmesan or red pepper flakes if you like more heat.

Leftovers? Let the dish cool, then store in an airtight container in the fridge for up to 3 days. To reheat, warm on the stove with a splash of cream or milk to bring the sauce back to life. Avoid microwaving on high, as the sauce can separate.

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Frequently Asked Questions

How spicy is this dish?

The spice level depends on your Cajun seasoning. Most blends offer medium heat, but you can reduce the amount if you’re spice-sensitive or add more for extra kick.

Can I use another type of pasta?

Absolutely! Fettuccine, rigatoni, or even rotini work great—just choose a pasta shape that holds sauce well.

What can I substitute for heavy cream?

Half-and-half or whole milk can be used, though the sauce will be slightly thinner. For a dairy-free version, try unsweetened coconut cream.

Is this recipe freezer-friendly?

It’s best enjoyed fresh, but you can freeze it. Let it cool completely, then freeze in portions. Thaw in the fridge overnight and reheat gently on the stove.

Can I make it vegetarian?

Yes! Skip the chicken and use seasoned roasted veggies like zucchini, mushrooms, or bell peppers.

How do I make it even creamier?

Add an extra handful of mozzarella or a spoonful of cream cheese for a richer, thicker sauce.

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Want More Pasta Ideas That Bring the Heat and Comfort?

If this Creamy Cajun Chicken Penne Pasta is your kind of comfort food, then don’t miss these other savory stars:

• Creamy Garlic Parmesan Tortellini with Sausage and Broccoli
• Cheesesteak Tortellini in Rich Provolone Sauce
• Creamy Garlic Marry Me Salmon
• Creamy Cajun Steak Alfredo Recipe
• One Pot Creamy Beef and Garlic Butter Pasta

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And let me know in the comments how yours turned out. Did you toss in extra veggies or up the spice? Maybe tried it with shrimp?

I love hearing how others make these recipes their own. Questions are welcome too—let’s help each other cook better, bolder meals.

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