Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce

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If you’re craving bold Southern comfort with a melty, cheesy twist, this Creamy Cajun Chicken Rotini is about to become your go-to indulgence. Picture perfectly seasoned Cajun chicken, seared until golden, nestled over rotini pasta that’s bathed in a rich garlic mozzarella sauce. The flavor is bold yet balanced—smoky from the Cajun spices, smooth from the melted cheese, and a hint of garlic warmth that brings everything together beautifully.

This dish is weeknight-easy but fancy enough to serve for guests. It combines everyday pantry ingredients with a touch of Louisiana flair. The rotini holds on to every drop of that velvety sauce, while the juicy chicken brings texture and protein-packed satisfaction. Whether you’re cooking for one or feeding a hungry crowd, this creamy pasta has major comfort food energy with minimal fuss.

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What Kind of Cajun Seasoning Should I Use?

You can go store-bought or homemade—both will deliver flavor, but homemade gives you more control over heat and salt. Look for a blend with paprika, garlic powder, onion powder, cayenne, oregano, and thyme. If you’re using a pre-mixed version like Slap Ya Mama or Tony Chachere’s, taste it first to ensure the salt level works for your dish.

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Ingredients for the Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce

• Rotini Pasta: Its twisty shape is perfect for soaking up the creamy sauce.
• Chicken Breasts: Boneless and skinless, seasoned generously with Cajun spice and seared to juicy perfection.
• Mozzarella Cheese: For that signature stretchy melt that makes the sauce luscious.
• Heavy Cream: The base of our garlic mozzarella sauce—it creates a thick and dreamy texture.
• Fresh Garlic: Infuses the sauce with savory depth and a bit of kick.
• Parmesan Cheese: Adds saltiness and richness to balance the mozzarella.
• Olive Oil: For searing the chicken and building flavor.
• Butter: Adds richness to the sauce and helps cook the garlic gently.
• Salt & Black Pepper: Essential for seasoning every layer.
• Chopped Parsley: Optional, but adds freshness and color as a final touch.

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How To Make the Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce

Step 1: Prep and Season the Chicken

Start by patting the chicken breasts dry with a paper towel. Coat them evenly with Cajun seasoning, ensuring all sides are well covered. Let them rest while you prep your other ingredients, allowing the flavors to soak in.

Step 2: Cook the Pasta

Bring a large pot of salted water to a boil and cook the rotini according to package instructions until al dente. Drain and set aside, tossing lightly in olive oil to prevent sticking.

Step 3: Sear the Chicken

In a large skillet over medium-high heat, add a drizzle of olive oil. Sear the seasoned chicken breasts for 5–7 minutes on each side or until they are golden brown and fully cooked. Remove from the skillet and let them rest before slicing.

Step 4: Make the Garlic Mozzarella Sauce

Lower the heat to medium. In the same skillet, add butter and minced garlic. Cook for about 1–2 minutes until fragrant but not browned. Pour in the heavy cream, then stir in shredded mozzarella and grated Parmesan. Stir continuously until the cheeses melt and the sauce thickens.

Step 5: Combine Pasta and Sauce

Add the drained rotini directly into the sauce and toss gently until every piece is coated. You can add a splash of pasta water if the sauce needs thinning.

Step 6: Slice and Serve

Slice the rested Cajun chicken and lay it over the creamy rotini. Sprinkle chopped parsley on top for a burst of color and freshness.

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Serving and Storing Creamy Cajun Chicken Rotini

Serve this creamy Cajun chicken rotini straight from the skillet while it’s still warm and gooey. The cheese will be stretchy, the sauce rich, and the Cajun spices at peak flavor. Pair it with a simple side salad or roasted green beans for a balanced meal.

If you’re making it ahead or have leftovers, store them in an airtight container in the refrigerator for up to 3 days. To reheat, add a splash of cream or milk to a skillet or microwave-safe bowl and warm gently to revive the sauce’s creaminess. It reheats beautifully, making it a great choice for lunch the next day.

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Frequently Asked Questions

How spicy is this dish?

That depends on your Cajun seasoning. If you’re sensitive to heat, reduce the amount or use a mild blend. You can always add a dash of hot sauce if you want more kick.

Can I use a different type of pasta?

Absolutely. Penne, rigatoni, or even fettuccine work well, but rotini holds the sauce especially well due to its ridges.

What’s the best substitute for heavy cream?

You can use half-and-half or a mix of whole milk and a tablespoon of butter. Keep in mind, the sauce may not be as thick or rich.

Can I add vegetables to this dish?

Yes! Spinach, sun-dried tomatoes, or even broccoli would mix in beautifully and add some color and nutrients.

Is this freezer-friendly?

Not really. The sauce tends to separate after freezing and thawing. It’s best enjoyed fresh or from the fridge within a few days.

Can I use pre-cooked chicken?

You can, but for maximum flavor, freshly seared Cajun chicken brings more depth. If you’re in a rush, rotisserie chicken tossed with Cajun spices can work in a pinch.

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Want More Pasta Recipes with a Kick?

If you’re loving this Creamy Cajun Chicken Rotini, then these other bold and creamy pasta dishes might be right up your alley:

• Cheesesteak Tortellini in Rich Provolone Sauce for Philly-inspired comfort.
• Creamy Garlic Parmesan Tortellini with Sausage and Broccoli when you want that savory-meets-creamy profile.
• One Pot Creamy Beef and Garlic Butter Pasta for quick weeknight indulgence.
• Creamy Cajun Steak Alfredo if you’re in the mood for steak instead of chicken.
• Creamy Cheesy Garlic Butter Rigatoni with Savory Beef that combines robust flavors in every bite.

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📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And I’d love to hear how your version turns out! Did you swap in shrimp or add spinach? Maybe used penne instead of rotini? Let me know in the comments so we can keep this delicious experiment going.

For more creamy, cheesy, and crave-worthy meal ideas, don’t forget to follow me on Pinterest: Life with Jam Recipes

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