Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

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A plate of creamy Cajun chicken rotini is the kind of comfort food that hits all the right notes: tender rotini pasta coated in a velvety mozzarella Alfredo sauce, paired with perfectly seasoned, pan-seared Cajun chicken. The pasta soaks up every bit of that rich, cheesy sauce, while the chicken brings a smoky, spicy kick that keeps each bite exciting. It’s indulgent yet easy enough to whip up for a weeknight dinner.

This dish combines the heartiness of Southern comfort food with the boldness of Cajun spices. The contrast between the creamy, garlicky Alfredo and the crispy, seasoned chicken is what makes it unforgettable. Serve it up for family dinner, date night, or even a casual gathering — it’s bound to become a new favorite in your recipe rotation.

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What Kind of Cajun Seasoning Should I Use?

A good Cajun seasoning blend should have a balance of paprika, garlic powder, onion powder, oregano, thyme, cayenne, and black pepper. You can buy a pre-made blend for convenience, but making your own allows you to control the heat and saltiness to suit your taste.

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Ingredients for the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

• Rotini pasta – Its spiral shape clings to the sauce, ensuring each bite is creamy and flavorful.
• Chicken breasts – Boneless and skinless for quick cooking and easy slicing.
• Cajun seasoning – Adds smoky, spicy depth to the chicken.
• Olive oil – Helps achieve a golden sear on the chicken.
• Butter – Forms the base of the Alfredo sauce and adds richness.
• Garlic – Freshly minced for aromatic depth.
• Heavy cream – The foundation of a silky Alfredo sauce.
• Mozzarella cheese – Melts into the cream for a stretchy, luscious texture.
• Parmesan cheese – Adds sharp, nutty flavor to balance the richness.
• Fresh parsley – For a pop of color and freshness.

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How To Make the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil. Add rotini and cook according to package instructions until al dente. Reserve about 1/2 cup of pasta water, then drain and set aside.

Step 2: Season and Sear the Chicken

Pat chicken breasts dry with paper towels. Coat them generously with Cajun seasoning on both sides. Heat olive oil in a large skillet over medium-high heat. Cook chicken for 4-5 minutes per side, or until golden brown and cooked through (internal temperature should reach 165°F). Transfer to a plate and let rest before slicing.

Step 3: Make the Mozzarella Alfredo Sauce

In the same skillet, reduce heat to medium and add butter. Once melted, stir in minced garlic and cook for about 1 minute until fragrant. Pour in heavy cream and bring to a gentle simmer. Stir in mozzarella and Parmesan cheese until melted and smooth. Adjust thickness with reserved pasta water if needed.

Step 4: Combine Pasta and Sauce

Add the cooked rotini to the skillet with the sauce. Toss until pasta is fully coated and creamy.

Step 5: Serve and Garnish

Slice the rested chicken and arrange it over the pasta. Sprinkle with freshly chopped parsley for a burst of color and freshness. Serve immediately while hot and cheesy.

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Serving and Storing Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

This pasta is best served fresh while the sauce is hot and silky. Pair it with a crisp green salad or garlic bread for a complete meal. For a little extra Cajun flair, sprinkle a pinch of additional seasoning over the chicken just before serving.

Leftovers can be stored in an airtight container in the refrigerator for up to 3 days. To reheat, add a splash of cream or milk to revive the sauce and warm gently on the stovetop or in the microwave.

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Frequently Asked Questions

Can I use a different type of pasta?

Yes! Penne, fettuccine, or rigatoni all work well, though rotini holds the sauce exceptionally well.

Can I make this dish less spicy?

Simply reduce the amount of Cajun seasoning or choose a mild blend.

Can I use pre-cooked chicken?

Yes, but searing raw chicken in the skillet adds more flavor to the sauce.

Is mozzarella necessary in the Alfredo sauce?

While traditional Alfredo uses Parmesan, mozzarella makes the sauce creamier and gives it that stretchy, indulgent texture.

Can I freeze this pasta?

Freezing is not recommended as the cream sauce may separate upon thawing.

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Want More Pasta Ideas with Bold Flavor?

If you love this creamy Cajun chicken rotini, you’ll probably enjoy these other flavorful pasta dishes:

• Rattlesnake Pasta for a spicy, cheesy kick.
• Creamy Cheesy Garlic Butter Rigatoni with Savory Beef for rich, garlicky comfort.
• Creamy Cajun Steak Alfredo if you want to swap chicken for tender steak.
• One-Pot Creamy Beef and Garlic Butter Pasta for a fuss-free weeknight dinner.
• Creamy Mushroom and Asparagus Chicken Penne for a veggie-forward twist.

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📌 Save this recipe to your Pinterest dinner board so you can come back to it anytime.

And let me know in the comments how yours turned out. Did you use extra Cajun seasoning for more heat? Did you try it with shrimp instead of chicken?

I love hearing how others make these recipes their own. Questions are welcome too — let’s help each other cook smarter.

Find more of my daily recipes on my Pinterest page Life with Jam.

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