A plate of sizzling garlic chicken bites, tender shrimp, and rich, creamy Cajun Alfredo pasta with spinach and artichokes is more than just dinner—it’s an event. This dish brings together everything you crave: juicy protein, a velvety cheesy sauce, and layers of bold Southern flavor all tangled up in a swirl of fettuccine.

Imagine the aroma of garlic sizzling in butter, followed by golden seared chicken and plump shrimp getting tossed in Cajun seasoning. Then comes the pasta: bathed in a luxurious sauce infused with Parmesan, cream, spinach, artichokes, and just enough Cajun kick to make your taste buds dance. It’s a feast that feels indulgent but is easy enough to pull off on a weeknight.

What Kind of Pasta Should I Use?

Fettuccine is our go-to here, and for good reason. Its wide, sturdy strands hold onto the creamy Cajun Alfredo sauce like a dream. If you’re in a pinch, linguine or tagliatelle also work beautifully. Want to make it low-carb? Try zucchini noodles or spaghetti squash—they’ll soak up all that sauce without missing a beat.

Ingredients for the Garlic Chicken Bites & Creamy Cajun Spinach Artichoke Alfredo Pasta

Chicken Thighs or Breasts – Juicy, flavorful, and perfect for searing with garlic and Cajun spices.

Shrimp (optional but highly recommended) – Adds a touch of sweetness and variety to the plate.

Fettuccine Pasta – The ultimate pasta for creamy sauces, thick enough to carry all the flavor.

Garlic – Essential for that punchy, savory aroma in both the chicken and the sauce.

Cajun Seasoning – Brings heat, smokiness, and bold Southern flavor.

Heavy Cream – The base of your Alfredo sauce, giving it richness and body.

Parmesan Cheese – Nutty, salty, and absolutely necessary for classic Alfredo.

Cream Cheese – Adds a smooth tang and extra creaminess.

Spinach – Fresh or frozen, it melts beautifully into the sauce.

Artichoke Hearts – A briny, tender addition that pairs perfectly with creamy sauces.

Olive Oil + Butter – Used for searing proteins and building depth in your sauce.

Salt & Pepper – To bring balance and enhance all the other flavors.

How To Make the Garlic Chicken Bites & Creamy Cajun Spinach Artichoke Alfredo Pasta

Step 1: Prep the Ingredients

Start by seasoning your chicken and shrimp (if using) with Cajun seasoning, salt, and pepper. Chop garlic, artichoke hearts, and spinach. Bring a large pot of salted water to a boil for your pasta.

Step 2: Sear the Chicken and Shrimp

Heat olive oil and butter in a large skillet over medium-high heat. Add chicken and sear for 4–5 minutes on each side until golden and cooked through. Remove and set aside. If using shrimp, cook them in the same pan for 1–2 minutes per side. Set aside with the chicken.

Step 3: Cook the Pasta

Drop your fettuccine into the boiling water and cook according to package directions until al dente. Reserve 1/2 cup of pasta water before draining.

Step 4: Build the Alfredo Base

In the same skillet, melt butter and add minced garlic. Sauté until fragrant. Stir in heavy cream and cream cheese, whisking until smooth. Slowly add grated Parmesan and stir until the sauce is creamy and cohesive.

Step 5: Add the Spinach and Artichokes

Fold in chopped spinach and artichokes, letting them simmer in the sauce for 2–3 minutes until tender. Add reserved pasta water to loosen the sauce if needed.

Step 6: Combine Everything

Add the drained pasta directly into the skillet and toss until well coated. Return chicken and shrimp to the pan, nestling them into the sauce. Let everything mingle over low heat for a few minutes to soak up the flavors.

Step 7: Serve and Garnish

Plate the pasta and top with the chicken and shrimp. Sprinkle on extra Parmesan, cracked black pepper, and chopped parsley if desired. Serve hot and enjoy!

How to Serve and Store This Garlic Chicken Bites & Creamy Cajun Spinach Artichoke Alfredo Pasta

This dish is all about comfort, so serve it hot, fresh from the skillet. It’s best plated family-style so everyone can get a bit of everything—those garlicky chicken bites, Cajun-kissed shrimp, and rich pasta twisted with spinach and artichokes. A garnish of freshly chopped parsley or basil adds a pop of color and freshness. Crusty bread or garlic toast on the side? Highly recommended.

To store leftovers, allow everything to cool completely before transferring to an airtight container. It will keep in the fridge for up to 3 days. To reheat, warm gently on the stove with a splash of cream or milk to bring the sauce back to life.

Frequently Asked Questions

What’s the best chicken to use?

Boneless, skinless chicken thighs are juicy and forgiving, but breasts work just as well if you prefer leaner meat.

Can I make this recipe ahead of time?

You can cook the components (chicken, shrimp, sauce) a day in advance and store them separately. Just reheat and combine when ready to serve.

Is it possible to make it vegetarian?

Absolutely. Skip the chicken and shrimp and double up on the spinach and artichokes. You can even toss in mushrooms or roasted red peppers.

Can I freeze the leftovers?

Cream-based sauces don’t freeze well—they tend to separate when thawed. It’s better to enjoy this dish fresh or refrigerated within a few days.

How spicy is this dish?

The Cajun seasoning gives it a kick, but it’s not overwhelming. For a milder version, use less seasoning or choose a low-sodium Cajun blend.

What should I serve on the side?

Keep it simple. A crisp green salad, roasted asparagus, or garlic bread make great pairings without overpowering the main dish.

Want More Pasta Dinner Ideas?

If this Garlic Chicken Bites & Creamy Cajun Spinach Artichoke Alfredo Pasta hit the spot, you’ll love exploring more comforting and flavor-packed recipes like these:

Try the Cheesesteak Tortellini in Rich Provolone Sauce for a meaty, cheesy twist that’s perfect for a cozy night in.
Dig into Creamy Garlic Parmesan Tortellini with Sausage and Broccoli for a hearty dinner packed with savory bites and bold flavor.
Craving something indulgent yet simple? The Creamy Tortellini Recipe is pure comfort in a bowl.
For a pasta dish that packs a punch, Red Pepper Rigatoni brings just the right balance of heat and cream.
And if you’re after something baked and satisfying, the Cheesy Baked Tortellini with Meat Sauce never disappoints.

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And when you make it, don’t forget to leave a comment below. Did you go spicy with extra Cajun? Did you sneak in mushrooms or use a different pasta? I’d love to hear how you made this dish your own.

For even more recipes like this, check out my daily creations on Pinterest at Life with Jam. Let’s keep the comfort food flowing!

Garlic Chicken Bites & Creamy Cajun Spinach Artichoke Alfredo Pasta

Author: Jam Scott
Total Time: 40 minutes
Yield: 4 servings

Print Recipe

Description

This Garlic Chicken Bites & Creamy Cajun Spinach Artichoke Alfredo Pasta is a rich, flavorful dinner featuring golden seared chicken, buttery shrimp, and fettuccine tossed in a creamy Cajun Alfredo sauce loaded with spinach and artichokes. It’s a comforting, restaurant-worthy meal made right at home—perfect for family dinners or impressing guests.

Instructions

1. Season the chicken and shrimp with Cajun seasoning, salt, and pepper. Chop garlic, spinach, and artichokes. Bring a pot of salted water to boil.

2. Heat olive oil and 1 tablespoon of butter in a skillet over medium-high heat. Sear the chicken for 4–5 minutes per side until golden and cooked. Set aside. Sear shrimp for 1–2 minutes per side. Set aside.

3. Cook the fettuccine until al dente. Reserve 1/2 cup of pasta water and drain.

4. In the same skillet, melt remaining butter and sauté garlic until fragrant. Stir in cream and cream cheese. Whisk until smooth.

5. Add Parmesan cheese and stir until the sauce is cohesive and creamy.

6. Fold in spinach and artichokes. Simmer for 2–3 minutes. Use pasta water to adjust thickness.

7. Add pasta to the skillet and toss to coat. Return chicken and shrimp to the pan. Simmer everything together for 2–3 minutes.

8. Serve immediately with extra Parmesan, black pepper, and chopped parsley if desired.

Notes

Let cream cheese soften before adding—it blends easier into hot cream.

If using frozen spinach, thaw and squeeze out excess water to avoid a watery sauce.

To avoid overcooked shrimp, sear them separately and add them back at the end.

Prep Time: 15 minutes
Cook Time: 25 minutes
Category: Dinner
Method: Stovetop
Cuisine: Cajun American

Nutrition

Serving Size: 1 plate
Calories: 635
Sugar: 3g
Sodium: 670mg
Fat: 38g
Saturated Fat: 18g
Unsaturated Fat: 16g
Trans Fat: 0g
Carbohydrates: 42g
Fiber: 4g
Protein: 35g
Cholesterol: 190mg

Keywords: garlic chicken, Cajun Alfredo, creamy pasta