Penne with Creamy Velveeta Four-Cheese and Cajun Beef Bites

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There’s something irresistible about a plate that combines velvety, cheese-coated pasta with juicy, spice-crusted bites of beef. This Penne with Creamy Velveeta Four-Cheese and Cajun Beef Bites recipe delivers exactly that — a satisfying, indulgent meal that feels like both a hug and a celebration.

The penne is bathed in a decadent sauce made from Velveeta Four-Cheese, giving it a melt-in-your-mouth creaminess that clings to every bite. On the side, Cajun-seasoned beef cubes are seared until crusty on the outside, yet tender and juicy within, adding smoky spice and meaty depth that perfectly balances the richness of the pasta.

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What Kind of Beef Should I Use for Cajun Beef Bites?

For the juiciest, most flavorful bites, choose a well-marbled cut like sirloin, ribeye, or even tenderloin for an extra luxe version. The marbling ensures the meat stays moist and succulent during the quick sear, while the Cajun seasoning brings that crave-worthy heat.

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Ingredients for Penne with Creamy Velveeta Four-Cheese and Cajun Beef Bites

• Penne pasta – Ridged surface helps the cheese sauce cling for maximum flavor.
• Velveeta Four-Cheese – Melts into a luxuriously smooth, rich sauce.
• Heavy cream – Adds richness and smoothness.
• Butter – Enhances flavor and silky texture.
• Cajun seasoning – Provides smoky heat.
• Sirloin or ribeye steak – Cubed for juicy, tender bites.
• Olive oil – Helps sear the beef to perfection.
• Salt & pepper – Balances and enhances flavors.

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How To Make Penne with Creamy Velveeta Four-Cheese and Cajun Beef Bites

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil. Add the penne and cook until al dente, following package instructions. Drain and set aside.

Step 2: Prepare the Beef Bites

Toss the steak cubes with olive oil, Cajun seasoning, salt, and pepper. Heat a skillet over medium-high heat and sear the beef in batches until browned on the outside and cooked to your preferred doneness. Remove and keep warm.

Step 3: Make the Cheese Sauce

In a saucepan, melt butter over medium heat. Add heavy cream and bring to a gentle simmer. Stir in Velveeta Four-Cheese until fully melted and smooth.

Step 4: Combine Pasta and Sauce

Add the cooked penne to the sauce, tossing until evenly coated.

Step 5: Serve

Plate the creamy pasta alongside the Cajun beef bites. Garnish with a sprinkle of Cajun seasoning or fresh herbs if desired.

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Serving and Storing

Serve this dish hot for the ultimate cheesy comfort. Store leftovers in an airtight container in the fridge for up to 3 days. Reheat gently with a splash of cream to revive the sauce’s silky texture.

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Frequently Asked Questions

Can I use another pasta shape?

Yes! Rigatoni, fusilli, or shells work beautifully.

How spicy is Cajun seasoning?

It varies by brand — taste yours first and adjust to preference.

Can I prepare the beef ahead of time?

You can sear it earlier, but for best results, cook just before serving.

Is there a lighter alternative to heavy cream?

Half-and-half works, though the sauce will be slightly less rich.

Can I use a different cheese?

Sharp cheddar or a blend of cheddar and mozzarella will also work.

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Want More Pasta and Beef Ideas?

If you love this dish, you’ll also enjoy these:

• Creamy Cheesy Garlic Butter Rigatoni with Savory Beef
• One-Pot Creamy Beef and Garlic Butter Pasta
• Creamy Cajun Steak Alfredo
• Rattlesnake Pasta

For more delicious recipes, visit my Pinterest – Life with Jam.

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Let me know in the comments how yours turned out. Did you keep it classic or add your own twist? I love hearing how others make these recipes their own.

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