This Creamy Cajun Chicken Spaghetti is comfort food turned gourmet. Imagine juicy blackened chicken slices resting atop perfectly twirled spaghetti, all drenched in a luscious garlic mozzarella sauce that’s thick, cheesy, and full of bold flavor. Every bite delivers a smoky Cajun kick softened by the velvety cream sauce and that irresistible cheese pull we all crave.

Whether you’re making this for a cozy weeknight dinner or showing off at your next gathering, this dish brings Southern charm and Italian soul to your table. It’s a beautiful balance of spice, creaminess, and heartiness that will have everyone asking for seconds.

What Makes a Great Cajun Chicken Spaghetti?

The magic lies in the layers of flavor. Cajun seasoning adds heat and earthiness to the chicken, while a homemade garlic mozzarella sauce keeps everything rich and indulgent. The seared crust on the chicken locks in moisture and adds a smoky depth that’s essential to contrast the creamy sauce.

For pasta, spaghetti holds onto the sauce just right, giving you the perfect swirl with each forkful. Add a sprinkle of chopped parsley and maybe a little more shredded cheese on top, and you’ve got a plate that feels like a warm hug.

Ingredients for the Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Chicken Breast: Lean, juicy, and perfect for taking on Cajun seasoning.
Cajun Seasoning: Brings smoky heat and depth to the dish. Use homemade or your favorite store-bought blend.
Spaghetti: The pasta of choice here—it holds the creamy sauce beautifully.
Heavy Cream: Makes the sauce luxuriously rich and smooth.
Mozzarella Cheese: Melty and mild, it gives that signature cheesy stretch.
Garlic (fresh minced): For bold, savory flavor in the sauce.
Butter: Adds richness to the garlic sauce base.
Olive Oil: Helps sear the chicken and adds flavor.
Parsley (chopped): For a fresh, herby finish.
Salt & Black Pepper: To season every layer to perfection.

How To Make the Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Step 1: Season and Sear the Chicken

Pat the chicken breasts dry and generously coat them with Cajun seasoning, salt, and pepper. Heat olive oil in a large skillet over medium-high heat. Sear the chicken for 4–5 minutes per side, or until cooked through and nicely blackened. Remove from the skillet and let rest.

Step 2: Cook the Spaghetti

Boil a large pot of salted water and cook the spaghetti according to package directions until al dente. Reserve 1/2 cup of the pasta water, then drain the rest.

Step 3: Make the Garlic Mozzarella Sauce

In the same skillet used for the chicken, melt butter over medium heat. Add minced garlic and sauté until fragrant (about 1 minute). Pour in the heavy cream and bring to a gentle simmer. Stir in shredded mozzarella until fully melted and smooth. If the sauce is too thick, add a splash of the reserved pasta water to loosen it up.

Step 4: Toss the Pasta

Add the cooked spaghetti directly into the sauce and toss until every strand is coated in cheesy garlic goodness. Season with extra salt and pepper to taste.

Step 5: Slice and Serve

Slice the rested chicken and layer it over the creamy spaghetti. Sprinkle with fresh parsley and extra mozzarella if desired. Serve hot and watch the cheese stretch!

How to Serve and Store This Creamy Cajun Chicken Spaghetti

Serve this dish immediately while the sauce is hot and the cheese is melty. It pairs beautifully with garlic bread, a crisp Caesar salad, or even roasted veggies.

To store leftovers, transfer the pasta and chicken into an airtight container. Refrigerate for up to 3 days. To reheat, add a splash of milk or cream and warm it gently on the stove or in the microwave to revive the creaminess.

Frequently Asked Questions

How spicy is this dish?

It’s moderately spicy thanks to the Cajun seasoning, but you can control the heat by using less or choosing a milder blend.

Can I use pre-cooked chicken?

Yes, you can! Just slice it and warm it up with a bit of oil and Cajun spice before adding it to the pasta.

What kind of mozzarella should I use?

Low-moisture shredded mozzarella melts the best without making the sauce watery.

Can I substitute another pasta?

Definitely—fettuccine or linguine also work great with this creamy sauce.

How do I prevent the sauce from clumping?

Use freshly shredded cheese and add it slowly to the warm cream while stirring constantly.

Want More Pasta Recipes Bursting with Flavor?

If you love this Creamy Cajun Chicken Spaghetti, check out these other crave-worthy dishes:

And for more daily recipes and kitchen inspiration, follow along on my Pinterest: Life with Jam on Pinterest

📌 Save this recipe to your Pinterest pasta board so you can whip it up whenever the craving hits.

Let me know in the comments how yours turned out! Did you add extra cheese? Try a different pasta shape? Swap in shrimp or sausage?

Your tips help others make it even better. And if you have questions, don’t be shy—drop them below and let’s chat about all things creamy and Cajun!

Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Author: Jam Scott
Total Time: 30 minutes
Yield: 4 servings

Print Recipe

Description

This Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce is the perfect blend of smoky heat, cheesy richness, and comforting pasta. Juicy Cajun-spiced chicken rests over tender spaghetti, all coated in a silky, garlic-forward mozzarella cream sauce. It’s a weeknight favorite or an impressive meal for guests!

Instructions

1. Pat chicken breasts dry and coat with Cajun seasoning, salt, and pepper.

2. Heat olive oil in a skillet over medium-high heat. Sear chicken for 4–5 minutes per side until blackened and cooked through. Remove and let rest.

3. Cook spaghetti in salted boiling water according to package directions. Reserve ½ cup pasta water, then drain.

4. In the same skillet, melt butter over medium heat. Sauté minced garlic until fragrant (about 1 minute).

5. Add heavy cream and bring to a gentle simmer. Stir in mozzarella cheese until melted and creamy. Add a splash of reserved pasta water if needed to thin the sauce.

6. Toss in the cooked spaghetti and coat well in the sauce. Adjust seasoning with salt and pepper.

7. Slice the rested chicken and place over the pasta. Garnish with fresh parsley and more mozzarella if desired.

8. Serve immediately while hot and cheesy!